ACUTE
CALCULOUS
CHOLECYSTITIS
Sonographic
Examination
of
Gallbladder:
The
gallbladder
is
generally
imaged
with
patients
in
both
supine
and
posterior
oblique
(LPO)
positions.
Upright
and,
on
occasion,
prone
scans
may
be
helpful
to
visualize
very
small
gallstones.
When
stones
are
not
immediately
apparent,
the
region
of
the
cystic
duct
and
neck
of
the
gallbladder
should
carefully
be
scrutinized
for
stones
in
both
transverse
and
sagittal
views.
When
a
gallstone
is
identified
in
the
neck
of
the
gallbladder,
it
is
important
to
scan
the
patient
in
multiple
positions
to
determine
if
the
stone
is
impacted.
All
patients
with
acute
right
upper
quadrant
pain
should
be
evaluated
for
sonographic
signs
of
acute
cholecystitis.
Sonography
of
the
gallbladder
is
best
performed
with
a
5-MHz
curved
array
transducer.
A
5-MHz
linear
array
transducer
may
be
helpful
in
patients
with
very
superficial
gallbladders.
In
obese
patients
or
in
patients
with
difficult
sonographic
access,
a
3,5-MHz
sector
or
curved
linear
transducer
is
necessary.
Role
of
Sonography
in
Diagnosis
of
Acute
Calculous
Cholecystitis:
Sonography
has
diagnostic
accuracies
exceeding
90%
for
suspected
acute
calculous
cholecystitis.
It
is
preferred
as
a
initial
imaging
study
due
to
several
clear
advantages
in
the
evaluation
of
patients
with
possible
acute
cholecystitis:
-
It
is
less
expensive
than
other
techniques.
-
It
often
can
be
performed
and
interpreted
more
quickly.
-
It
provides
considerably
more
anatomic
information.
-
It
can
definitely
diagnose
gallstones
as
well
as
other
important
secondary
findings
(se
below).
-
It
is
independent
of
hepatic
function
and
biliary
obstruction
(unlike
scintigraphy).
-
It
may
be
performed
at
the
bedside
in
critically
ill
patients.
-
In
patients
with
gangrenous
cholecystitis,
sonography
may
guide
percutaneous
cholecystostomy
when
clinically
appropriate.
-
Sonography
can
survey
the
entire
abdomen
if
the
gallbladder
is
normal
(an
important
capability
as
only
a
minority
of
patients
referred
for
imaging
with
right
upper
quadrant
pain
prove
to
have
cholecystitis).
Despite
these
advantages,
sonography
has
a
number
of
significant
limitations
in
the
diagnosis
of
acute
cholecystitis:
-
Cystic
duct
stones
may
be
missed
due
to
the
small
lumen
of
the
cystic
duct
and
lack
of
surrounding
bile.
-
While
cystic
duct
obstruction
can
generally
be
inferred
when
a
stone
is
identified
impacted
in
the
neck
of
the
gallbladder,
sonography
cannot
directly
diagnose
cystic
duct
obstruction.
Sonographic
Diagnosis
of
Acute
Calculous
Cholecystitis:
Gallstones
are
the
single
most
important
finding.
In
the
absence
of
stones,
other
observations,
such
as
wall
thickening
or
focal
tenderness
over
the
gallbladder
(sonographic
Murphy's
sign)
are
diagnostic.
The
sonographic
Murphy's
sign
is
an
important
finding
in
suspected
acute
cholecystitis.
It
differs
significantly
from
the
clinical
sign
and
refers
to
focal
tenderness
directly
over
the
gallbladder
when
pressure
is
applied
by
the
ultrasound
transducer.
Gangrenous
cholecystitis
may
cause
necrosis
and
denervation
of
afferent
nerve
fibers
from
the
gallbladder
and
result
in
a
negative
sonographic
Murphy's
sign.
However,
there
are
generally
other
significant
sonographic
abnormalities
such
as
gallstones,
wall
thickening,
or
pericholecystic
fluid
to
suggest
the
diagnosis
of
cholecystitis.
Thickening
of
the
gallbladder
wall
is
an
important
sonographic
observation
in
acute
cholecystitis.
The
normal
gallbladder
wall
measures
3mm
or
less.
Measurements
are
most
accurate
when
obtained
from
the
anterior
subhepatic
gallbladder
wall
using
a
long
axis
image.
This
avoids
side-lobe
artifacts
from
adjacent
bowel
gas
and
difficulties
encountered
by
dependent
intraluminal
sludge.
Measurements
of
the
gallbladder
wall
are
not
reliable
in
postprandial
patients
with
a
contracted
gallbladder.
Symmetric
thickening
of
the
gallbladder
wall
(Picture1)
is
often
not
related to
intrinsic
biliary
disease.
In
the
absence
of
gallstones,
this
finding
must
be
interpreted
with
caution
in
patients
with
possible
cholecystitis.
Generalized
gallbladder
wall
thickening
may
occur
in
a
broad
spectrum
of
other
disorders
including
hepatitis,
acquired
immunodeficiency
syndrome
(AIDS),
congestive
heart
failure,
hypoalbuminemia,
ascites,
hyperplastic
cholecystosis,
and
chronic
cholecystitis.

Picture
1.
Asymmetric
thickening
of
the
gallbladder
wall
may
be
due
to
carcinoma,
metastases,
adenomyomatosis,
or
gangrenous
cholecystitis.
Four
distinct
patterns
of
gallbladder
wall
thickening
have
been
identified
with
sonography:
-
A
striated
pattern
of
multiple
hypoechoic
layers
separated
by
echogenic
zones.
-
Asymmetric
thickening
of
the
gallbladder
wall
with
echogenic
tissue
projecting
into
the
gallbladder
lumen.
-
A
single
central
hypoechoic
zone
separated
by
two
echogenic
layers.
-
A
uniformly
echogenic
appearance.
Unfortunately,
no
one
pattern
of
wall
thickening
as
an
isolated
finding
is
specific
for
acute
cholecystitis.
Furthermore,
there
is
considerable
overlap
with
many
other
causes
of
gallbladder
wall
thickening.
In
general,
sonography
is
the
most
reliable
technique
for
diagnosing
acute
cholecystitis,
if
multiple
signs
are
present
such
as
gallstones,
a
thickened
gallbladder
wall,
and
a
positive
sonographic
Murphy's
sign.
In
patients
with
a
sonographically
normal
gallbladder,
acute
cholecystitis
can
be
excluded
with
a
high
degree
of
confidence.
REFERENCES:
[1]Sonography
of
the
Abdomen.
R.B.Jeffrey,
P.W.Rolls.
1995
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